mgc87693; zona pellucida glycoprotein 1; zona pellucida glycoprotein 1 (sperm receptor); zp1; zp1 protein
Categories
Primary Antibodies
Clonality
polyclonal
Description
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.Hughes D.C., Biochim. Biophys. Acta 1447:303-306(1999).Taylor T.D., Nature 440:497-500(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ZP1.
Involvement In Disease
Oocyte maturation defect 1 (OOMD1)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Hughes D.C., Biochim. Biophys. Acta 1447:303-306(1999). Taylor T.D., Nature 440:497-500(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ZP1 protein.
Subcellular Location
Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Protein Families
ZP domain family, ZPB subfamily
Tissue Specificity
Oocytes.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.