14-3-3 protein T-cell; 14-3-3 protein tau; 1433T; 143T; HS1 protein
Antigen
YWHAQ
Categories
Primary Antibodies
Clonality
polyclonal
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.Nielsen P.J., Biochim. Biophys. Acta 1088:425-428(1991).Leffers H., J. Mol. Biol. 231:982-998(1993).Gevaert K., Nat. Biotechnol. 21:566-569(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human 14-3-3 θ.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Nielsen P.J., Biochim. Biophys. Acta 1088:425-428(1991). Leffers H., J. Mol. Biol. 231:982-998(1993). Gevaert K., Nat. Biotechnol. 21:566-569(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total 14-3-3 θ protein.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.