Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus By similarity.Nezu J., Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.Ni X., Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.Ota T., Nat. Genet. 36:40-45(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human VRK3.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus By similarity.
Nezu J., Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. Ni X., Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total VRK3 protein.
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.
Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.