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Home / Antibodies

USP15 Antibody

SKU : BHA10558741

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA040632
Alternative Names	Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Deubiquitinating enzyme 15; Unph-2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.Kim K.I., Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.Nagase T., DNA Res. 5:31-39(1998).Nakajima D., DNA Res. 9:99-106(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human USP15.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Kim K.I., Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. Nagase T., DNA Res. 5:31-39(1998). Nakajima D., DNA Res. 9:99-106(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total USP15 protein.
Subcellular Location	Cytoplasm, Nucleus, Mitochondrion

Uniprot	Q9Y4E8
Database Links	HGNC:12613 OMIM:604731 KEGG:hsa:9958 STRING:9606.ENSP00000258123 UniGene:Hs.434951
Function	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways
Protein Families	Peptidase C19 family
Tissue Specificity	Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558741	CSB-PA040632	100ul	$297		Add to Cart

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