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Home / Antibodies

UBE2T Antibody

SKU : BHA10558754

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA212556
Alternative Names	Ubiquitin-conjugating enzyme E2 T; Ubiquitin-protein ligase T; Ubiquitin carrier protein T; UBE2T;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.Okaze H., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human UBE2T.
Involvement In Disease	Fanconi anemia complementation group T (FANCT)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Okaze H., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases. Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). Zhang Q.-H., Genome Res. 10:1546-1560(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total UBE2T protein.
Subcellular Location	Nucleus

Uniprot	Q9NPD8
Database Links	HGNC:25009 OMIM:610538 KEGG:hsa:29089 STRING:9606.ENSP00000356243 UniGene:Hs.5199
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway
Protein Families	Ubiquitin-conjugating enzyme family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558754	CSB-PA212556	100ul	$297		Add to Cart

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