Tumor necrosis factor ligand superfamily member 14; Herpesvirus entry mediator-ligand; HVEM-L; CD258 antigen; Tumor necrosis factor ligand superfamily member 14
Antigen
TNFSF14
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.Mauri D.N., Immunity 8:21-30(1998).Harrop J.A., J. Biol. Chem. 273:27548-27556(1998).Granger S.W., J. Immunol. 167:5122-5128(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human TNF14.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Mauri D.N., Immunity 8:21-30(1998). Harrop J.A., J. Biol. Chem. 273:27548-27556(1998). Granger S.W., J. Immunol. 167:5122-5128(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TNF14 protein.
Subcellular Location
Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Pathway
NF-kappa B signaling pathway
Protein Families
Tumor necrosis factor family
Tissue Specificity
Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tu
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.