Metalloproteinase inhibitor 3 [Precursor]; TIMP-3; Tissue inhibitor of metalloproteinases 3; Protein MIG-5; TIMP3
Antigen
TIMP3
Categories
Primary Antibodies
Clonality
polyclonal
Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.Uria J.A., Cancer Res. 54:2091-2094(1994).Wilde C.G., DNA Cell Biol. 13:711-718(1994).Silbiger S.M., Gene 141:293-297(1994).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human TIMP3.
Involvement In Disease
Sorsby fundus dystrophy (SFD)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Uria J.A., Cancer Res. 54:2091-2094(1994). Wilde C.G., DNA Cell Biol. 13:711-718(1994). Silbiger S.M., Gene 141:293-297(1994).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TIMP3 protein.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Protein Families
Protease inhibitor I35 (TIMP) family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.