Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.Suzuki K., EMBO J. 6:1891-1897(1987).Wen D., Biochemistry 26:4350-4357(1987). Jackman R.W., Proc. Natl. Acad. Sci. U.S.A. 84:6425-6429(1987).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human THBD.
Involvement In Disease
Thrombophilia due to thrombomodulin defect (THPH12); Hemolytic uremic syndrome atypical 6 (AHUS6)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Suzuki K., EMBO J. 6:1891-1897(1987). Wen D., Biochemistry 26:4350-4357(1987). Jackman R.W., Proc. Natl. Acad. Sci. U.S.A. 84:6425-6429(1987).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total THBD protein.