CYP5; CYP5A1; Cytochrome P450 5A1; cytochrome P450; family 5
Antigen
TBXAS1
Categories
Primary Antibodies
Clonality
polyclonal
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Yokoyama C., Biochem. Biophys. Res. Commun. 178:1479-1484(1991).Ohashi K., J. Biol. Chem. 267:789-793(1992).Miyata A., Eur. J. Biochem. 224:273-279(1994).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human THAS.
Involvement In Disease
Ghosal hematodiaphyseal dysplasia (GHDD)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Yokoyama C., Biochem. Biophys. Res. Commun. 178:1479-1484(1991). Ohashi K., J. Biol. Chem. 267:789-793(1992). Miyata A., Eur. J. Biochem. 224:273-279(1994).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total THAS protein.
Subcellular Location
Endoplasmic reticulum membrane, Multi-pass membrane protein