Solute carrier family 22 member 18; Organic cation transporter-like protein 2; ORCTL-2; Imprinted multi-membrane spanning polyspecific transporter-related protein 1; Efflux transporter-like protein
Antigen
SLC22A18
Categories
Primary Antibodies
Clonality
polyclonal
Description
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.Lee M.P., Cancer Res. 58:4155-4159(1998).Morisaki H., DNA Res. 5:235-240(1998).Cooper P.R., Genomics 49:38-51(1998).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human ORCTL-2.
Involvement In Disease
Lung cancer (LNCR); Rhabdomyosarcoma, embryonal, 1 (RMSE1)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Lee M.P., Cancer Res. 58:4155-4159(1998). Morisaki H., DNA Res. 5:235-240(1998). Cooper P.R., Genomics 49:38-51(1998).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ORCTL-2 protein.
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Protein Families
Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
Tissue Specificity
Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.