Endophilin-1; SH3 domain-containing GRB2-like protein 2; SH3 domain protein 2A; EEN-B1;
Antigen
SH3GL2
Categories
Primary Antibodies
Clonality
polyclonal
Description
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.Giachino C., Genomics 41:427-434(1997).So C.W., Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SH3GL2.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.
Giachino C., Genomics 41:427-434(1997). So C.W., Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SH3GL2 protein.
Subcellular Location
Cytoplasm, Membrane, Peripheral membrane protein, Early endosome
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Pathway
Endocytosis
Protein Families
Endophilin family
Tissue Specificity
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.