May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway(PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2(By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
Host
Rabbit
Immunogen
sestrin 3
Isotype
IgG
Molecular Weight
51-59 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
SEST3
Uniprot
P58005
Gene Id
143686
Research Area
Cardiovascular
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)