Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1
Antigen
SCN4A
Categories
Primary Antibodies
Clonality
polyclonal
Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.George A.L. Jr., Ann. Neurol. 31:131-137(1992).Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992).Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human SCN4A.
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
George A.L. Jr., Ann. Neurol. 31:131-137(1992). Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992). Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total SCN4A protein.
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.