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Home / Antibodies

SAE1 Antibody

SKU : BHA10559778

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA794022
Alternative Names	AOS1; HSPC140; SAE1; SUA1; SUMO-1 activating enzyme E1 N subunit
Categories	Primary Antibodies
Clonality	polyclonal
Description	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.Yoshiaki Azuma, FASEB J, Jun 2001; 10.1096.Walter Makous, Invest. Ophthalmol. Vis. Sci., Sep 2006; 47: 4160 - 4167. Hsin-Pei Shih, J. Cell Sci., Mar 2002; 115: 1259. Thomas Buschmann, J. Biol. Chem., Oct 2001; 276: 40389 - 40395.
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human AOS1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Yoshiaki Azuma, FASEB J, Jun 2001; 10.1096. Walter Makous, Invest. Ophthalmol. Vis. Sci., Sep 2006; 47: 4160 - 4167. Hsin-Pei Shih, J. Cell Sci., Mar 2002; 115: 1259. Thomas Buschmann, J. Biol. Chem., Oct 2001; 276: 40389 - 40395.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total AOS1 protein.
Subcellular Location	Nucleus

Uniprot	Q9UBE0
Gene Id	10055
Database Links	HGNC:30660 OMIM:613294 KEGG:hsa:10055 STRING:9606.ENSP00000270225 UniGene:Hs.515500
Function	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Pathway	Ubiquitin mediated proteolysis
Protein Families	Ubiquitin-activating E1 family
Tissue Specificity	Expression level increases during S phase and drops in G2 phase (at protein level).
Weight	38 kDa

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559778	CSB-PA794022	100ul	$297		Add to Cart

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