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Home / Antibodies

RRP8 Antibody

SKU : BHA10558333

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA249711
Alternative Names	KIAA0409;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.Ishikawa K., DNA Res. 4:307-313(1997).The MGC Project Team; Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human HUCE1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. Ishikawa K., DNA Res. 4:307-313(1997). The MGC Project Team; Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total HUCE1 protein.
Subcellular Location	Nucleus, nucleolus

Uniprot	O43159
Database Links	HGNC:29030 OMIM:615818 KEGG:hsa:23378 STRING:9606.ENSP00000254605 UniGene:Hs.652255
Function	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell
Protein Families	Methyltransferase superfamily, RRP8 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558333	CSB-PA249711	100ul	$297		Add to Cart

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