Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1;
Antigen
RIN1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.Colicelli J., Proc. Natl. Acad. Sci. U.S.A. 88:2913-2917(1991).Han L., Mol. Cell. Biol. 15:1318-1323(1995).Han L., Proc. Natl. Acad. Sci. U.S.A. 94:4954-4959(1997)
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human RIN1.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Colicelli J., Proc. Natl. Acad. Sci. U.S.A. 88:2913-2917(1991). Han L., Mol. Cell. Biol. 15:1318-1323(1995). Han L., Proc. Natl. Acad. Sci. U.S.A. 94:4954-4959(1997)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RIN1 protein.
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Pathway
Ras signaling pathway
Protein Families
RIN (Ras interaction/interference) family
Tissue Specificity
Expressed in all tissues examined with high levels in brain, placenta and pancreas.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.