protein tyrosine phosphatase type IVA; PRL3; PRL-R; PTP4A3;
Antigen
PTP4A3
Categories
Primary Antibodies
Clonality
polyclonal
Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.Matter W.F. et.al. Biochem. Biophys. Res. Commun. 283:1061-1068(2001)Wang J.et.al. J. Biol. Chem. 277:46659-46668(2002)
Host
Rabbit
Immunogen
Peptide sequence around aa. 161-166 (K-D-P-H-T) derived from Human PTP4A3.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Matter W.F. et.al. Biochem. Biophys. Res. Commun. 283:1061-1068(2001) Wang J.et.al. J. Biol. Chem. 277:46659-46668(2002)
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Protein Families
Protein-tyrosine phosphatase family
Tissue Specificity
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.