Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.Tsurumi C., Eur. J. Biochem. 239:912-921(1996).The MGC Project Team, Genome Res. 14:2121-2127(2004).Dunbar J.D., J. Immunol. 158:4252-4259(1997).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human PSMD2.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Tsurumi C., Eur. J. Biochem. 239:912-921(1996). The MGC Project Team, Genome Res. 14:2121-2127(2004). Dunbar J.D., J. Immunol. 158:4252-4259(1997).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total PSMD2 protein.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Protein Families
Proteasome subunit S2 family
Tissue Specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.