May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons Charest-Marcotte A,et al. (2010)Genes Dev.24(6):537-42.Huang Y,et al.(2010) Mol Vis.16:341-52.Hanai S,et al.(2010) Seizure.19(5):274-9.
Host
Rabbit
Immunogen
Peptide sequence around aa.723~727 (E-I-F-K-S) derived from Human Prospero homeobox protein 1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses
Protein Families
Prospero homeodomain family
Tissue Specificity
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.