Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6;
Antigen
PNPLA6
Categories
Primary Antibodies
Clonality
polyclonal
Description
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.Lucas S.M., Nature 428:529-535(2004).Venter J.C., Submitted (SEP-2005).Korner R., Anal. Chem. 80:9526-9533(2008).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human PNPLA6.
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Lucas S.M., Nature 428:529-535(2004). Venter J.C., Submitted (SEP-2005). Korner R., Anal. Chem. 80:9526-9533(2008).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total PNPLA6 protein.
Subcellular Location
Endoplasmic reticulum membrane, Single-pass type I membrane protein, Cytoplasmic side
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Protein Families
NTE family
Tissue Specificity
Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.