Phospho-VEGFR2 (Tyr1059) Antibody

Mfr.No.	AF3279
Alternative Names	CD309 ; CD309 antigen ; EC 2.7.10.1 ; Fetal liver kinase 1 ; FLK-1 ; FLK1 ; FLK1, mouse, homolog of ; Kdr ; Kinase insert domain receptor (a type III receptor tyrosine kinase) ; Kinase insert domain receptor ; KRD1 ; Ly73 ; Protein tyrosine kinase receptor FLK1 ; Protein-tyrosine kinase receptor flk-1 ; soluble VEGFR2 ; Tyrosine kinase growth factor receptor ; Vascular endothelial growth factor receptor 2 ; VEGFR 2 ; VEGFR ; VEGFR-2 ; VEGFR2 ; VGFR2_HUMAN ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	VEGFR-2 is a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2.
Immunogen	A synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyrosine 1059.
Molecular Weight	Observed Mol.Wt.: 170kDa. Predicted Mol.Wt.: 152kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-VEGFR2 (Tyr1059) Antibody detects endogenous levels of VEGFR2 only when phosphorylated at Tyrosine 1059.
Subcellular Location	Membrane.

Uniprot

P35968

Gene Id

3791

Sequence

10	20	30	40	50
MQSKVLLAVA	LWLCVETRAA	SVGLPSVSLD	LPRLSIQKDI	LTIKANTTLQ
60	70	80	90	100
ITCRGQRDLD	WLWPNNQSGS	EQRVEVTECS	DGLFCKTLTI	PKVIGNDTGA
110	120	130	140	150
YKCFYRETDL	ASVIYVYVQD	YRSPFIASVS	DQHGVVYITE	NKNKTVVIPC
160	170	180	190	200
LGSISNLNVS	LCARYPEKRF	VPDGNRISWD	SKKGFTIPSY	MISYAGMVFC
210	220	230	240	250
EAKINDESYQ	SIMYIVVVVG	YRIYDVVLSP	SHGIELSVGE	KLVLNCTART
260	270	280	290	300
ELNVGIDFNW	EYPSSKHQHK	KLVNRDLKTQ	SGSEMKKFLS	TLTIDGVTRS
310	320	330	340	350
DQGLYTCAAS	SGLMTKKNST	FVRVHEKPFV	AFGSGMESLV	EATVGERVRI
360	370	380	390	400
PAKYLGYPPP	EIKWYKNGIP	LESNHTIKAG	HVLTIMEVSE	RDTGNYTVIL
410	420	430	440	450
TNPISKEKQS	HVVSLVVYVP	PQIGEKSLIS	PVDSYQYGTT	QTLTCTVYAI
460	470	480	490	500
PPPHHIHWYW	QLEEECANEP	SQAVSVTNPY	PCEEWRSVED	FQGGNKIEVN
510	520	530	540	550
KNQFALIEGK	NKTVSTLVIQ	AANVSALYKC	EAVNKVGRGE	RVISFHVTRG
560	570	580	590	600
PEITLQPDMQ	PTEQESVSLW	CTADRSTFEN	LTWYKLGPQP	LPIHVGELPT
610	620	630	640	650
PVCKNLDTLW	KLNATMFSNS	TNDILIMELK	NASLQDQGDY	VCLAQDRKTK
660	670	680	690	700
KRHCVVRQLT	VLERVAPTIT	GNLENQTTSI	GESIEVSCTA	SGNPPPQIMW
710	720	730	740	750
FKDNETLVED	SGIVLKDGNR	NLTIRRVRKE	DEGLYTCQAC	SVLGCAKVEA
760	770	780	790	800
FFIIEGAQEK	TNLEIIILVG	TAVIAMFFWL	LLVIILRTVK	RANGGELKTG
810	820	830	840	850
YLSIVMDPDE	LPLDEHCERL	PYDASKWEFP	RDRLKLGKPL	GRGAFGQVIE
860	870	880	890	900
ADAFGIDKTA	TCRTVAVKML	KEGATHSEHR	ALMSELKILI	HIGHHLNVVN
910	920	930	940	950
LLGACTKPGG	PLMVIVEFCK	FGNLSTYLRS	KRNEFVPYKT	KGARFRQGKD
960	970	980	990	1000
YVGAIPVDLK	RRLDSITSSQ	SSASSGFVEE	KSLSDVEEEE	APEDLYKDFL
1010	1020	1030	1040	1050
TLEHLICYSF	QVAKGMEFLA	SRKCIHRDLA	ARNILLSEKN	VVKICDFGLA
1060	1070	1080	1090	1100
RDIYKDPDYV	RKGDARLPLK	WMAPETIFDR	VYTIQSDVWS	FGVLLWEIFS
1110	1120	1130	1140	1150
LGASPYPGVK	IDEEFCRRLK	EGTRMRAPDY	TTPEMYQTML	DCWHGEPSQR
1160	1170	1180	1190	1200
PTFSELVEHL	GNLLQANAQQ	DGKDYIVLPI	SETLSMEEDS	GLSLPTSPVS
1210	1220	1230	1240	1250
CMEEEEVCDP	KFHYDNTAGI	SQYLQNSKRK	SRPVSVKTFE	DIPLEEPEVK
1260	1270	1280	1290	1300
VIPDDNQTDS	GMVLASEELK	TLEDRTKLSP	SFGGMVPSKS	RESVASEGSN
1310	1320	1330	1340	1350
QTSGYQSGYH	SDDTDTTVYS	SEEAELLKLI	EIGVQTGSTA	QILQPDSGTT

LSSPPV

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.