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Home / Primary Antibodies

Phospho-TPH2 (Ser19) Antibody

SKU : BHA10560246

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA123981
Alternative Names	ADHD7; NTPH; TPH2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.Walther D.J., Science 299:76-76(2003).Scherer S.E., Nature 440:346-351(2006).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2.
Involvement In Disease	Major depressive disorder (MDD); Attention deficit-hyperactivity disorder 7 (ADHD7)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. Walther D.J., Science 299:76-76(2003). Scherer S.E., Nature 440:346-351(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.

Uniprot	Q8IWU9
Database Links	HGNC:20692 OMIM:607478 KEGG:hsa:121278 STRING:9606.ENSP00000329093 UniGene:Hs.736576
Protein Families	Biopterin-dependent aromatic amino acid hydroxylase family
Tissue Specificity	Brain specific.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560246	CSB-PA123981	100ul	$360		Add to Cart

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