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Home / Antibodies

Phospho-TH (Ser19) Antibody

SKU : BHA10559966

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA439504
Alternative Names	TY3H; TYH; Tyrosine 3-hydroxylase; tyrosine hydroxylase;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.Vazin T, et al. Stem Cells. 2008 Jun;26(6):1517-25Pistocchi A, et al. BMC Dev Biol. 2008 Mar 10;8:27 Fukakusa A, et al. J Pharmacol Sci. 2008 Feb;106(2):321-4.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine19 (A-V-S(p)-E-Q) derived from Rat Tyrosine Hydroxylase (TH).
Involvement In Disease	Segawa syndrome autosomal recessive (ARSEGS)
Raised In	Rabbit
Reactivity	Rat
Regulatory	RUO
Relevance	The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. Vazin T, et al. Stem Cells. 2008 Jun;26(6):1517-25 Pistocchi A, et al. BMC Dev Biol. 2008 Mar 10;8:27 Fukakusa A, et al. J Pharmacol Sci. 2008 Feb;106(2):321-4.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Tyrosine Hydroxylase only when phosphorylated at serine19.

Uniprot	P07101
Database Links	HGNC:11782 OMIM:191290 KEGG:hsa:7054 STRING:9606.ENSP00000370571 UniGene:Hs.435609
Function	Plays an important role in the physiology of adrenergic neurons.
Protein Families	Biopterin-dependent aromatic amino acid hydroxylase family
Tissue Specificity	Mainly expressed in the brain and adrenal glands.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:200

Tested Application

ELISA,IF;IF:1:100-1:200

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559966	CSB-PA439504	100ul	$360		Add to Cart

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