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Home / Primary Antibodies

Phospho-SYT1/SYT2 (Thr202/199) Antibody

SKU : BHA10559945

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA562323
Alternative Names	SYT1/2; SytI/II; Synaptotagmin I/II; P65; SYT
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse Gustavsson N, et al. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3992-7. Cnops L, et al. Cereb Cortex. 2008 May; 18(5):1221-31. Lynch KL, et al. Mol Biol Cell. 2007 Dec; 18(12):4957-68.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 202/199 (R-K-T(p)-L-N) derived from Human Synaptotagmin 1/2.
Involvement In Disease	A SYT1 rare mutation has been found in a child with a severe neuro-developmental disorder. The individual harboring this variant shows early onset dyskinetic movement disorder, severe motor delay and profound cognitive impairment, suggesting that SYT1 may play a role in the pathogenesis of this neuro-developmental disorder.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse Gustavsson N, et al. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3992-7. Cnops L, et al. Cereb Cortex. 2008 May; 18(5):1221-31. Lynch KL, et al. Mol Biol Cell. 2007 Dec; 18(12):4957-68.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Synaptotagmin 1/2 only when phosphorylated at threonine202/199.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle membrane, Single-pass membrane protein, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Single-pass membrane protein, Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Single-pass membrane protein, Cytoplasm

Uniprot	P21579
Database Links	HGNC:11509 OMIM:185605 KEGG:hsa:6857 STRING:9606.ENSP00000261205 UniGene:Hs.310545
Function	May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes
Pathway	Synaptic vesicle cycle
Protein Families	Synaptotagmin family
Tissue Specificity	Expressed in melanocytes (PubMed:23999003).

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:200

Tested Application

ELISA,IF;IF:1:100-1:200

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559945	CSB-PA562323	100ul	$360		Add to Cart

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