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Home / Primary Antibodies

Phospho-SMAD1 (Ser206) Antibody

SKU : BHA10559988

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA224827
Alternative Names	Mad-related protein 1; SMAD 1; hSMAD1; Transforming growth factor-beta-signaling protein 1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).Hiroaki Seto, et al. (2004) J Clin Invest. March 1; 113(5): 718
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 206 (P-H-S(p)-P-T) derived from Human Smad1.
Involvement In Disease	SMAD1 variants may be associated with susceptibility to pulmonary hypertension, a disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). Hiroaki Seto, et al. (2004) J Clin Invest. March 1; 113(5): 718
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Smad1 only when phosphorylated at serine 206.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q15797
Database Links	HGNC:6767 OMIM:601595 KEGG:hsa:4086 STRING:9606.ENSP00000305769 UniGene:Hs.604588
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Pathway	Hippo signaling pathway TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells
Protein Families	Dwarfin/SMAD family
Tissue Specificity	Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559988	CSB-PA224827	100ul	$360		Add to Cart

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