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Home / Primary Antibodies

Phospho-MAP2K7 (Thr275) Antibody

BHA10560191
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Uniprot O14733
Database Links

HGNC:6847

OMIM:603014

KEGG:hsa:5609

STRING:9606.ENSP00000381066

UniGene:Hs.531754
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Pathway ErbB signaling pathway MAPK signaling pathway TNF signaling pathway Protein processing in endoplasmic reticulum Fc epsilon RI signaling pathway Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway Neurotrophin signaling pathway
Protein Families Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Tissue Specificity Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format liquid
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Applications ELISA, WB
Description ELISA ; WB, WB ; ELISA
Dilution

WB1:500-1:1000
Tested Application ELISA,WB;WB:1:500-1:1000
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
SKU Supplier No. Size Your price Quantity
BHA10560191 CSB-PA583333 100ul $360
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