Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of serine 535 or serine 539 (D-S(p)-G-N-Y-S(p)-N) derived from Human Interferon-a Receptor Type I Subunit I.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of MEK5 only when phosphorylated at serine 535 or 539.