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Home / Antibodies

Phospho-HDAC7 (Ser155) Antibody

SKU : BHA10560241

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA264510
Alternative Names	HD7a; HDA7; HDAC7A;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Walsh M.J., Submitted (FEB-2000).Zelent A., Submitted (MAY-2003).Sugano S., Nat. Genet. 36:40-45(2004)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 155(T-V-S(p)-E-P) derived from Human HDAC7A.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Walsh M.J., Submitted (FEB-2000). Zelent A., Submitted (MAY-2003). Sugano S., Nat. Genet. 36:40-45(2004)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of HDAC7A only when phosphorylated at serine 155.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	Q8WUI4
Database Links	HGNC:14067 OMIM:606542 KEGG:hsa:51564 STRING:9606.ENSP00000080059 UniGene:Hs.200063
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3
Protein Families	Histone deacetylase family, HD type 2 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560241	CSB-PA264510	100ul	$360		Add to Cart

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