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Home / Antibodies

Phospho-GRIA1 (Ser849) Antibody

SKU : BHA10559952

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA580841
Alternative Names	GLR1; GLUH1; GRIA1; GluR-1; GluR-A
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Emamian ES, et al. (2004) J Neurosci. 24(7): 1561-4Palmer, C.L. et al. (2005) Pharmacol. Rev. 57, 253-277.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 849 (Q-Q-S(p)-I-N ) derived from Human GluR1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Emamian ES, et al. (2004) J Neurosci. 24(7): 1561-4 Palmer, C.L. et al. (2005) Pharmacol. Rev. 57, 253-277.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of GluR1 only when phosphorylated at serine 849.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Multi-pass membrane protein, Cell projection, dendrite, Cell projection, dendritic spine, Early endosome membrane, Multi-pass membrane protein, Recycling endosome membrane, Multi-pass membrane protein

Uniprot	P42261
Gene Id	2890
Database Links	HGNC:4571 OMIM:138248 KEGG:hsa:2890 STRING:9606.ENSP00000285900 UniGene:Hs.519693
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Pathway	cAMP signaling pathway Glutamatergic synapse
Protein Families	Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA1 subfamily
Tissue Specificity	Widely expressed in brain.
Weight	102kDa

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559952	CSB-PA580841	100ul	$360		Add to Cart

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