One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725.Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519.Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255.Merry L. Lindsey, Circulation, Jun 2006; 113: 2919 - 2928.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of Serine 265(Q-K-Y(p)-A-Y) derived from Human Connexin 43.
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725. Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519. Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255. Merry L. Lindsey, Circulation, Jun 2006; 113: 2919 - 2928.
Species
Homo Sapiens (Human)
Specificity
Connexin 43 antibody detects endogenous levels of Connexin 43 only when phosphorylated at Serine 265
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity
Pathway
Gap junction
Protein Families
Connexin family, Alpha-type (group II) subfamily
Tissue Specificity
Expressed in the heart and fetal cochlea.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.