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Home / Primary Antibodies

Phospho-GAB1 (Tyr627) Antibody

SKU : BHA10560399

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA827140
Alternative Names	Growth factor receptor bound protein 2-associated protein 1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.Anders Kallin, et al. (2004) J. Biol. Chem 279: 17897 - 17904.Hideto Kameda, et al. (2001) Cell Growth Differ 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol 158: 773.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 - 17904. Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Gab1 only when phosphorylated at tyrosine 627.

Uniprot	Q13480
Database Links	HGNC:4066 OMIM:604439 KEGG:hsa:2549 STRING:9606.ENSP00000262995 UniGene:Hs.618456
Function	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Pathway	ErbB signaling pathway Ras signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway
Protein Families	GAB family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:1000
IF	1:100-1:200

Tested Application

ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560399	CSB-PA827140	100ul	$360		Add to Cart

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