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Home / Primary Antibodies

Phospho-EPOR (Tyr368) Antibody

SKU : BHA10560153

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA598485
Alternative Names	EPO R; EPO-R; epor;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y(p)-L-V) derived from Human Epo-R.
Involvement In Disease	Erythrocytosis, familial, 1 (ECYT1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Epo-R only when phosphorylated at tyrosine 368.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform EPOR-S: Secreted

Uniprot	P19235
Database Links	HGNC:3416 OMIM:133100 KEGG:hsa:2057 STRING:9606.ENSP00000222139 UniGene:Hs.631624
Function	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; FUNCTION
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage
Protein Families	Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity	Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EP

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560153	CSB-PA598485	100ul	$360		Add to Cart

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