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Home / Antibodies

Phospho-AIRE (Ser156) Antibody

SKU : BHA10560214

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA217298
Alternative Names	AIRE1; APECED; APS1; APSI; PGA1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. Nagamine K., Nat. Genet. 17:393-398(1997).Aaltonen J., Nat. Genet. 17:399-403(1997).Hattori M., Nature 405:311-319(2000).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine156 P-G-S(p)-Q-L) derived from Human AIRE.
Involvement In Disease	Autoimmune polyendocrine syndrome 1, with or without reversible metaphyseal dysplasia (APS1)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. Nagamine K., Nat. Genet. 17:393-398(1997). Aaltonen J., Nat. Genet. 17:399-403(1997). Hattori M., Nature 405:311-319(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of AIRE only when phosphorylated at serine 156.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	O43918
Gene Id	326
Database Links	HGNC:360 OMIM:109100 KEGG:hsa:326 STRING:9606.ENSP00000291582 UniGene:Hs.129829
Function	Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA)
Pathway	Ubiquitin mediated proteolysis
Tissue Specificity	Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expres

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560214	CSB-PA217298	100ul	$360		Add to Cart

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