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Home / Primary Antibodies

Phospho-ABL1 (Tyr412) Antibody

BHA10560430
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Tel
+1 866.986.9598
Email
[email protected]
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Uniprot P00519
Gene Id 25
Database Links

HGNC:76

OMIM:189980

KEGG:hsa:25

STRING:9606.ENSP00000361423

UniGene:Hs.431048
Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717'
Pathway ErbB signaling pathway Cell cycle Ras signaling pathway Neurotrophin signaling pathway
Protein Families Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
Tissue Specificity Widely expressed.
Weight 124,955 Da
Buffer Purified Rabbit polyclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Form Liquid
Format liquid
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Description IF ; ELISA ; IHC
Tested Application ELISA, IHC, IF; IHC:1:50-1:100, IF:1:100-1:200
Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
SKU Supplier No. Size Your price Quantity
BHA10560430 CSB-PA980598 100ul $360
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