Pleckstrin homology-like domain family A member 1; T-cell death-associated gene 51 protein; Apoptosis-associated nuclear protein; Proline- and histidine-rich protein; Proline- and glutamine-rich protein
Antigen
PHLDA1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.Kuske M.D., Cytogenet. Cell Genet. 89:1-1(2000).Neef R., Cancer Res. 62:5920-5929(2002).Hinz T., Cell. Signal. 13:345-352(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human PHLA1.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
Kuske M.D., Cytogenet. Cell Genet. 89:1-1(2000). Neef R., Cancer Res. 62:5920-5929(2002). Hinz T., Cell. Signal. 13:345-352(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total PHLA1 protein.
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
Tissue Specificity
Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.