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Home / Primary Antibodies

Peroxiredoxin 4 Antibody / PRDX4 (V8955)

SKU : BHA17119479

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NSJ Bioreagents

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Mfr.No.	V8955, V8955-20UG, V8955-100UG
Clonality	Monoclonal (mouse origin)
Description	The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Mouse
Immunogen Region	Recombinant full-length human PRDX4 protein was used as the immunogen for the Peroxiredoxin 4 antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the Peroxiredoxin 4 antibody should be determined by the researcher.

Uniprot	Q13162

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the Peroxiredoxin 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA: 1-5ug/ml (order BSA-free format for coating)

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17119479-1	V8955-20UG	20ug	$219		Add to Cart
BHA17119479-2	V8955-100UG	100ug	$499		Add to Cart

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