Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.Braun I.C., EMBO J. 18:1953-1965(1999).Kang Y., Genes Dev. 13:1126-1139(1999).Bear J., Mol. Cell. Biol. 19:6306-6317(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human NXF1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
Braun I.C., EMBO J. 18:1953-1965(1999). Kang Y., Genes Dev. 13:1126-1139(1999). Bear J., Mol. Cell. Biol. 19:6306-6317(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total NXF1 protein.
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway)
Protein Families
NXF family
Tissue Specificity
Expressed ubiquitously.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.