Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.Virbasius C.A., Genes Dev. 7:2431-2445(1993).Efiok B.J.S., J. Biol. Chem. 269:18921-18930(1994).Gopalakrishnan L., J. Biol. Chem. 270:18019-18025(1995).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human NRF1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Virbasius C.A., Genes Dev. 7:2431-2445(1993). Efiok B.J.S., J. Biol. Chem. 269:18921-18930(1994). Gopalakrishnan L., J. Biol. Chem. 270:18019-18025(1995).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total NRF1 protein.
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Pathway
Apelin signaling pathway
Protein Families
NRF1/Ewg family
Tissue Specificity
Ubiquitously expressed with strongest expression in skeletal muscle.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.