The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A recombinant full-length human n-Myc protein was used as the immunogen for the n-Myc antibody.
Isotype
Mouse IgG2a, kappa
Species Reactivity
Human, Mouse, Rat
Note
Optimal dilution of the antibody should be determined by the researcher.
Uniprot
P04198
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the n-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).