DFNA4; myosin heavy chain; nonmuscle IIc; myosin-14; NHMCII
Antigen
MYH14
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping By similarity.Leal A., Gene 312:165-171(2003).Bienvenut W.V., Submitted (NOV-2006) to UniProtKB.Nagase T., Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human MYH14.
Involvement In Disease
Deafness, autosomal dominant, 4A (DFNA4A); Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping By similarity.
Leal A., Gene 312:165-171(2003). Bienvenut W.V., Submitted (NOV-2006) to UniProtKB. Nagase T., Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MYH14 protein.
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Pathway
Regulation of actin cytoskeleton
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity
High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.