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Home / Primary Antibodies

MNDA Antibody

SKU : BHA10558507

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA192245
Alternative Names	myeloid cell nuclear differentiation antigen; PYHIN3;
Categories	Primary Antibodies
Clonality	polyclonal
Description	The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.Briggs J.A., J. Cell. Biochem. 49:82-92(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004).Burrus G.R., J. Cell. Biochem. 48:190-202(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human MNDA.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. Briggs J.A., J. Cell. Biochem. 49:82-92(1992). The MGC Project Team; Genome Res. 14:2121-2127(2004). Burrus G.R., J. Cell. Biochem. 48:190-202(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MNDA protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	P41218
Database Links	HGNC:7183 OMIM:159553 KEGG:hsa:4332 STRING:9606.ENSP00000357123 UniGene:Hs.153837
Function	May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Tissue Specificity	Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558507	CSB-PA192245	100ul	$297		Add to Cart

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