May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.Fukunaga R., EMBO J. 16:1921-1933(1997).Knauf U., Mol. Cell. Biol. 21:5500-5511(2001).O'Loghlen A., Exp. Cell Res. 299:343-355(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human MKNK1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Fukunaga R., EMBO J. 16:1921-1933(1997). Knauf U., Mol. Cell. Biol. 21:5500-5511(2001). O'Loghlen A., Exp. Cell Res. 299:343-355(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MKNK1 protein.
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.