Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.Johnston S.H., Development 124:2245-2254(1997).Collins J.E., Genome Biol. 5:R84.1-R84.11(2004).Dunham I., Nature 402:489-495(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human MFNG.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.
Johnston S.H., Development 124:2245-2254(1997). Collins J.E., Genome Biol. 5:R84.1-R84.11(2004). Dunham I., Nature 402:489-495(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MFNG protein.
Subcellular Location
Golgi apparatus membrane, Single-pass type II membrane protein
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules
Pathway
Notch signaling pathway
Protein Families
Glycosyltransferase 31 family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.