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MECP2 Antibody

SKU : BHA10558926

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA912786
Alternative Names	AUTSX3; DKFZp686A24160; MeCp-2 protein; MECP2; methyl CpG binding protein 2 (Rett syndrome)
Categories	Primary Antibodies
Clonality	polyclonal
Description	Methyl-CpG-binding protein 2(MeCP2), whose exact function is unclear. It appears to help regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein usually regulates genes involved in brain function, even though this protein is found throughout the body.Within the brain, the MeCP2 protein is important for the function of nerve cells (neurons) and is present in high levels in mature neurons. This protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. Many of the genes that are known to be regulated by the MeCP2 protein play a role in normal brain function, particularly the maintenance of synapses.
Host	Rabbit
Involvement In Disease	Angelman syndrome (AS); Mental retardation, X-linked, syndromic, 13 (MRXS13); Rett syndrome (RTT); Autism, X-linked 3 (AUTSX3); Encephalopathy, neonatal severe, due to MECP2 mutations (ENS-MECP2); Mental retardation, X-linked, syndromic, Lubs type (MRXSL)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Methyl-CpG-binding protein 2(MeCP2), whose exact function is unclear. It appears to help regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein usually regulates genes involved in brain function, even though this protein is found throughout the body.Within the brain, the MeCP2 protein is important for the function of nerve cells (neurons) and is present in high levels in mature neurons. This protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. Many of the genes that are known to be regulated by the MeCP2 protein play a role in normal brain function, particularly the maintenance of synapses.
Species	Homo Sapiens (Human)
Specificity	MeCP2 rabbit polyclonal antibody detects endogenous MeCP2 proteins.
Subcellular Location	Nucleus

Uniprot	P51608
Database Links	HGNC:6990 OMIM:105830 KEGG:hsa:4204 STRING:9606.ENSP00000395535 UniGene:Hs.200716
Function	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Tissue Specificity	Present in all adult somatic tissues tested.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558926	CSB-PA912786	100ul	$297		Add to Cart

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