Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.Derijard B.,Science 267:682-685(1995).The MGC Project Team;Genome Res. 14:2121-2127(2004).Lim S.,J. Biol. Chem. 277:25040-25046(2002).
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human MAP2K3 around the phosphorylation site of threonine 222 (A-K-T(p)-M-D).
Involvement In Disease
Defects in MAP2K3 may be involved in colon cancer.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Pathway
MAPK signaling pathway TNF signaling pathway Cellular senescence Fc epsilon RI signaling pathway Toll-like receptor signaling pathway Rap1 signaling pathway
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Tissue Specificity
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.