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KRT10 Antibody

SKU : BHA10559753

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA998574
Alternative Names	Keratin type I cytoskeletal 10; Cytokeratin-10; CK-10; K10;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.XM Zhou, J. Biol. Chem., Oct 1988; 263: 15584 - 15589.Felix B. M篓绛秎er, Hum. Mol. Genet., Apr 2006; 15: 1133 - 1141.J Reichelt, J. Cell Sci., Sep 1997; 110: 2175.BP Korge, PNAS, Feb 1992; 89: 910.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Keratin 10.
Involvement In Disease	Epidermolytic hyperkeratosis (EHK); Ichthyosis annular epidermolytic (AEI); Erythroderma, ichthyosiform, congenital reticular (CRIE)
Raised In	Rabbit
Reactivity	Human, Rat
Regulatory	RUO
Relevance	This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. XM Zhou, J. Biol. Chem., Oct 1988; 263: 15584 - 15589. Felix B. M?er, Hum. Mol. Genet., Apr 2006; 15: 1133 - 1141. J Reichelt, J. Cell Sci., Sep 1997; 110: 2175. BP Korge, PNAS, Feb 1992; 89: 910.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Keratin 10 protein.

Uniprot	P13645
Database Links	HGNC:6413 OMIM:113800 KEGG:hsa:3858 STRING:9606.ENSP00000269576 UniGene:Hs.99936
Pathway	Estrogen signaling pathway
Protein Families	Intermediate filament family
Tissue Specificity	Seen in all suprabasal cell layers including stratum corneum.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559753	CSB-PA998574	100ul	$297		Add to Cart

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