KLF11; Krueppel-like factor 11; TGFB-inducible early growth response protein 2; TIEG-2; transforming growth factor-beta-inducible early growth response protein 2
Antigen
KLF11
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.Cook T., J. Biol. Chem. 273:25929-25936(1998).Asano H., Mol. Cell. Biol. 19:3571-3579(1999).Neve B., Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human KLF11.
Involvement In Disease
Maturity-onset diabetes of the young 7 (MODY7)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Cook T., J. Biol. Chem. 273:25929-25936(1998). Asano H., Mol. Cell. Biol. 19:3571-3579(1999). Neve B., Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total KLF11 protein.