Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.Wei W, et al. (2005). Cancer Cell. 8(1): 25-33.Sevilla A, et al. (2004). Oncogene.23 (55): 8950-8958.Li L, et al. (2004). J Biol Chem.279 (6): 4058-4065.Hurd C, et al. (2002). Oncogene.21 (14): 2154-2160.
Host
Rabbit
Immunogen
Peptide sequence around aa. 61~65 (L-T-S-P-D) derived from Human c-Jun.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
Wei W, et al. (2005). Cancer Cell. 8(1): 25-33. Sevilla A, et al. (2004). Oncogene.23 (55): 8950-8958. Li L, et al. (2004). J Biol Chem.279 (6): 4058-4065. Hurd C, et al. (2002). Oncogene.21 (14): 2154-2160.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total c-Jun protein.
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.