HGF receptor; HGF-SF receptor; Met proto-oncogene tyrosine kinase; c-met; kinase Met
Antigen
IRS1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.Fan S, et al. (2001) Mol Cell Biol; 21(15): 4968-4984Schiering N, et al. (2003) Proc Natl Acad Sci U S A; 100(22): 12654-12659Plopper GE, et al. (1995) Mol Biol Cell; 6(10): 1349-1365Ponzetto C, et al. (1993) Mol Cell Biol; 13(8): 4600-4608Jackson PA, et al. (2001) Plant Physiol; 127(3): 1065-1076
Host
Rabbit
Immunogen
Peptide sequence around aa.1347~1351 (E-H-Y-V-H) derived from Human Met.
Involvement In Disease
Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
Fan S, et al. (2001) Mol Cell Biol; 21(15): 4968-4984 Schiering N, et al. (2003) Proc Natl Acad Sci U S A; 100(22): 12654-12659 Plopper GE, et al. (1995) Mol Biol Cell; 6(10): 1349-1365 Ponzetto C, et al. (1993) Mol Cell Biol; 13(8): 4600-4608 Jackson PA, et al. (2001) Plant Physiol; 127(3): 1065-1076
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total Met protein.
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.