Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.Hosokawa Y., Genomics 61:326-329(1999).Liippo J.P., Eur. J. Immunol. 31:3469-3474(2001).Perdomo J., J. Biol. Chem. 275:38347-38354(2000).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human IKZF3.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Hosokawa Y., Genomics 61:326-329(1999). Liippo J.P., Eur. J. Immunol. 31:3469-3474(2001). Perdomo J., J. Biol. Chem. 275:38347-38354(2000).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total IKZF3 protein.
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Protein Families
Ikaros C2H2-type zinc-finger protein family
Tissue Specificity
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Weight
29,973 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.